195 Untangling the complex cytokine milieu in psoriasis and atopic dermatitis through organotypic epidermal models

A milieu of regulatory elements in the epidermal differentiation complex syntenic block: implications for atopic dermatitis and psoriasis.

Two common inflammatory skin disorders with impaired barrier, atopic dermatitis (AD) and psoriasis, share distinct genetic linkage to the Epidermal Differentiation Complex (EDC) locus on 1q21. The EDC is comprised of tandemly arrayed gene families encoding proteins involved in skin cell differentiation. Discovery of semi-dominant mutations in filaggrin (FLG) associated with AD and a copy number...

Psoriasis and Atopic Dermatitis

Psoriasis and atopic dermatitis are common, chronic inflammatory skin diseases. We discuss several aspects of these disorders, including: risk factors; incidence and prevalence; the complex disease burden; and the comorbidities that increase the clinical significance of each disorder. We also focus on treatment management strategies and outline why individualized, patient-centered treatment reg...

Pathogenesis of Atopic Dermatitis and Psoriasis: Focus on the Epidermal Differentiation Complex

Loss-of-function mutations in the FLG gene (encoding the epidermis-specific protein filaggrin) were recently shown to be associated with atopic dermatitis in several populations. These findings have challenged the dogma that atopic dermatitis is primarily an immune-mediated disease, and suggest skin barrier deficiency as a major cause. Similarly, psoriasis was until recently regarded as a T-cel...

Induction of Innate Immune Response Genes Compared to Psoriasis, Skin Prevents Cytokine Milieu of Atopic Dermatitis, as

Epidermal Barrier in Atopic Dermatitis

Atopic dermatitis (AD) is a complex disease that affects up to 20% of children and impacts the quality of patients and families in a significant manner. New insights into the pathophysiology of AD point to an important role of structural abnormalities in the epidermis combined with immune dysregulation. Filaggrin (FLG) is synthesized as a large precursor, profilaggrin, and is expressed in the u...